Poliosis as a manifestation of conjunctival melanoma.

appear to bind copper in these disease states but are not known to do so in vitro. In at least 1 case, the coppercarrying protein was sequenced in an attempt to determine whether it shared the N-terminal Asp-Ala-His amino acid sequence known to bind copper in albumin, but no such sequence was found. Sequences as simple as Gly-His are capable of binding copper under certain circumstances, especially if they are repeated, rendering it difficult to determine the location of a potential binding site based on sequence alone. Myeloma protein is known to accumulate in the eye as an amyloid, and although individual myeloma proteins do not appear to bind copper, closely packed myeloma proteins may be able to do so.